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LRP4 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O75096 |
| Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 212kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml) |
| Gene ID | 4038 |
|---|---|
| Other Names | Low-density lipoprotein receptor-related protein 4, LRP-4, Multiple epidermal growth factor-like domains 7, LRP4, KIAA0816, LRP10, MEGF7 |
| Target/Specificity | Human LRP4. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | LRP4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRP4 |
|---|---|
| Synonyms | KIAA0816, LRP10, MEGF7 |
| Function | Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8VI56}; Single-pass type I membrane protein |
| Tissue Location | Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
References
Ishikawa K.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Nakayama M.,et al.Genomics 51:27-34(1998).
Taylor T.D.,et al.Nature 440:497-500(2006).
Li Y.,et al.Am. J. Hum. Genet. 86:696-706(2010).
Leupin O.,et al.J. Biol. Chem. 286:19489-19500(2011).
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