|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog|
|Dilution||ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||Protein transport protein Sec61 subunit alpha isoform 1, Sec61 alpha-1, SEC61A1, SEC61A|
|Target/Specificity||Human SEC61A1 / SEC61.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SEC61A1 / SEC61 Antibody (aa463-476) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER).|
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Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins.
Liu T.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Li W.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Finke K.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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