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SEC61A1 / SEC61 Antibody (aa463-476)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P61619 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Dilution | ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 29927 |
|---|---|
| Other Names | Protein transport protein Sec61 subunit alpha isoform 1, Sec61 alpha-1, SEC61A1, SEC61A |
| Target/Specificity | Human SEC61A1 / SEC61. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | SEC61A1 / SEC61 Antibody (aa463-476) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC61A1 |
|---|---|
| Synonyms | SEC61A |
| Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:8616892). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). |
| Tissue Location | Expressed in proximal and distal tubules in kidney (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins.
References
Liu T.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Li W.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Finke K.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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