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>   home   >   Products   >   Primary Antibodies   >   TRF1 / TERF1 Antibody (clone BED5)   

TRF1 / TERF1 Antibody (clone BED5)

Mouse Monoclonal Antibody

     
  • IHC - TRF1 / TERF1 Antibody (clone BED5) ALS14280
    Anti-TRF1 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IHC-Fr
Primary Accession P54274
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names BED5
Calculated MW 50kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 7013
Other Names Telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, TERF1, PIN2, TRBF1, TRF, TRF1
Target/Specificity Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTRF1 / TERF1 Antibody (clone BED5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TERF1
Synonyms PIN2, TRBF1, TRF, TRF1
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle
Tissue Location Highly expressed and ubiquitous. Isoform Pin2 predominates
Citations (0)

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Background

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

References

Chong L.,et al.Science 270:1663-1667(1995).
de Lange T.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Broccoli D.,et al.Nat. Genet. 17:231-235(1997).
Shen M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:13618-13623(1997).
Nusbaum C.,et al.Nature 439:331-335(2006).

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$ 395.00
Cat# ALS14280
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