Mcpt4 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | P21812 |
Reactivity | Mouse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 27kDa |
Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), |
Gene ID | 17227 |
---|---|
Other Names | Mast cell protease 4, mMCP-4, 3.4.21.-, MSMCP, Myonase, Serosal mast cell protease, Mcpt4 |
Target/Specificity | Mouse MCPT4. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | Mcpt4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Mcpt4 |
---|---|
Function | Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala- 5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. |
Tissue Location | Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. |
Volume | 50 µl |
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Background
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta- protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing.
References
Serafin W.E.,et al.J. Biol. Chem. 266:1934-1941(1991).
Ge Y.,et al.Am. J. Pathol. 158:281-292(2001).
Huang R.,et al.Eur. J. Immunol. 21:1611-1621(1991).
Hori S.,et al.J. Biochem. 123:650-658(1998).
Reynolds D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3230-3234(1990).
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