|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP, DLGAP5, DLG7, KIAA0008|
|Target/Specificity||DLGAP5 Antibody detects endogenous levels of total DLGAP5 protein.|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||HURP / DLGAP5 Antibody (aa791-840) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells|
|Tissue Location||Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta|
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Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Tsou A.-P.,et al.Oncogene 22:298-307(2003).
Nomura N.,et al.DNA Res. 1:27-35(1994).
Ohara O.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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