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CMPK / CMPK1 Antibody (clone 1D7)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30085 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1D7 |
| Calculated MW | 22kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 51727 |
|---|---|
| Other Names | UMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}, 2.7.4.14 {ECO:0000255|HAMAP-Rule:MF_03172}, Deoxycytidylate kinase {ECO:0000255|HAMAP-Rule:MF_03172}, CK {ECO:0000255|HAMAP-Rule:MF_03172}, dCMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}, Nucleoside-diphosphate kinase {ECO:0000255|HAMAP-Rule:MF_03172}, 2.7.4.6 {ECO:0000255|HAMAP-Rule:MF_03172}, Uridine monophosphate/cytidine monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03172}, UMP/CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}, UMP/CMPK {ECO:0000255|HAMAP-Rule:MF_03172}, CMPK1 {ECO:0000255|HAMAP-Rule:MF_03172} |
| Target/Specificity | Human UMP/CMP kinase |
| Reconstitution & Storage | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Precautions | CMPK / CMPK1 Antibody (clone 1D7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CMPK1 {ECO:0000255|HAMAP-Rule:MF_03172} |
|---|---|
| Function | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132}. Note=Predominantly cytoplasmic, less than 15% nuclear. |
| Tissue Location | Ubiquitously expressed. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
References
Van Rompay A.R.,et al.Mol. Pharmacol. 56:562-569(1999).
Pearman A.T.,et al.Life Sci. 69:2361-2370(2001).
Liou J.-Y.,et al.Cancer Res. 62:1624-1631(2002).
Song H.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Fan Y.X.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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