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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DLD / Diaphorase / E3 Antibody (clone 3C1)   

DLD / Diaphorase / E3 Antibody (clone 3C1)

Mouse Monoclonal Antibody

     
  • WB - DLD / Diaphorase / E3 Antibody (clone 3C1) ALS14363
    Western blot of DLD expression in HeLa cell lysate.
  • IHC - DLD / Diaphorase / E3 Antibody (clone 3C1) ALS14363
    Anti-DLD / DLDH antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P09622
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C1
Calculated MW 54kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 1738
Other Names Dihydrolipoyl dehydrogenase, mitochondrial, 1.8.1.4, Dihydrolipoamide dehydrogenase, Glycine cleavage system L protein, DLD, GCSL, LAD, PHE3
Target/Specificity Human DLD
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsDLD / Diaphorase / E3 Antibody (clone 3C1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLD
Synonyms GCSL, LAD, PHE3
Function Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). In monomeric form has additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
Cellular Location Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}
Research Areas
Citations (0)

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Background

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.

References

Otulakowski G.,et al.J. Biol. Chem. 262:17313-17318(1987).
Pons G.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1422-1426(1988).
Feigenbaum A.S.,et al.Genomics 17:376-381(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14363
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