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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   HDAC1 Antibody (clone 3E1)   

HDAC1 Antibody (clone 3E1)

Mouse Monoclonal Antibody

     
  • WB - HDAC1 Antibody (clone 3E1) ALS14381
    Western blot of HDAC1 expression in HeLa nuclear extract.
  • WB - HDAC1 Antibody (clone 3E1) ALS14381
    Western blot of HDAC1 expression in NIH/3T3 cell lysate.
  • IF - HDAC1 Antibody (clone 3E1) ALS14381
    Immunofluorescence of monoclonal antibody to HDAC1 on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - HDAC1 Antibody (clone 3E1) ALS14381
    Anti-HDAC1 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13547
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 3E1
Calculated MW 55kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 3065
Other Names Histone deacetylase 1, HD1, 3.5.1.98, HDAC1, RPD3L1
Target/Specificity Human HDAC1
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsHDAC1 Antibody (clone 3E1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC1
Synonyms RPD3L1
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Cellular Location Nucleus.
Tissue Location Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain
Research Areas
Citations (0)

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Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

References

Taunton J.,et al.Science 272:408-411(1996).
Furukawa Y.,et al.Cytogenet. Cell Genet. 73:130-133(1996).
Sparrow D.B.,et al.EMBO J. 18:5085-5098(1999).
Huynh K.D.,et al.Genes Dev. 14:1810-1823(2000).
Cai R.L.,et al.J. Biol. Chem. 275:27909-27916(2000).

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$ 450.00
Cat# ALS14381
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