EIF2B2 Antibody (clone 5B12-E10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P49770 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 5B12-E10 |
Calculated MW | 39kDa |
Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
Gene ID | 8892 |
---|---|
Other Names | Translation initiation factor eIF-2B subunit beta, S20I15, S20III15, eIF-2B GDP-GTP exchange factor subunit beta, EIF2B2, EIF2BB |
Target/Specificity | Human EIF2B2 |
Reconstitution & Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | EIF2B2 Antibody (clone 5B12-E10) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EIF2B2 |
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Synonyms | EIF2BB |
Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9UT76} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
References
Yu W.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Sherrington R.,et al.Nature 375:754-760(1995).
Heilig R.,et al.Nature 421:601-607(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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