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PTPN6 / SHP1 Antibody

Mouse Monoclonal Antibody

     
  • WB - PTPN6 / SHP1 Antibody ALS14447
    0
  • IHC - PTPN6 / SHP1 Antibody ALS14447
    Anti-PTPN6 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P29350
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW 68kDa
Dilution IHC-P (1:200), WB (1:2000),
Additional Information
Gene ID 5777
Other Names Tyrosine-protein phosphatase non-receptor type 6, 3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsPTPN6 / SHP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN6
Synonyms HCP, PTP1C
Function Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Cellular Location Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Tissue Location Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

References

Yi T.,et al.Mol. Cell. Biol. 12:836-846(1992).
Shen S.H.,et al.Nature 352:736-739(1991).
Shen S.H.,et al.Nature 353:868-868(1991).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992).
Banville D.,et al.Genomics 27:165-173(1995).

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$ 395.00
Cat# ALS14447
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