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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC-10, FITC)   

KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC-10, FITC)

Mouse Monoclonal Antibody

     
  • IHC - KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC-10, FITC) ALS14475
    Anti-KRT18 / Cytokeratin 18 antibody IHC of human prostate, epithelium.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, Flo
Primary Accession P05783
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names DC-10
Calculated MW 48kDa
Dilution IF, IHC-P (1:50),
Additional Information
Gene ID 3875
Other Names Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
Target/Specificity The antibody DC-10 reacts with Cytokeratin 18 (45 kD). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
Reconstitution & Storage Store at +4°C. Do not freeze. Product is photosensitive and should be protected from light.
PrecautionsKRT18 / CK18 / Cytokeratin 18 Antibody (clone DC-10, FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

References

Oshima R.G.,et al.Differentiation 33:61-68(1986).
Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).

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$ 395.00
Cat# ALS14475
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