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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RICTOR Antibody (clone 1F3)   

RICTOR Antibody (clone 1F3)

Mouse Monoclonal Antibody

     
  • WB - RICTOR Antibody (clone 1F3) ALS14493
    RICTOR monoclonal antibody (M01), clone 1F3 Western blot of RICTOR expression in HeLa NE.
  • WB - RICTOR Antibody (clone 1F3) ALS14493
    Western blot of RICTOR expression in transfected 293T cell line by RICTOR monoclonal antibody...
  • IP - RICTOR Antibody (clone 1F3) ALS14493
    Immunoprecipitation of RICTOR transfected lysate using anti-RICTOR monoclonal antibody and...
  • IHC - RICTOR Antibody (clone 1F3) ALS14493
    Anti-RICTOR antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession Q6R327
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F3
Calculated MW 192kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 253260
Other Names Rapamycin-insensitive companion of mTOR, AVO3 homolog, hAVO3, RICTOR {ECO:0000312|EMBL:EAW55980.1}
Target/Specificity Human RICTOR
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsRICTOR Antibody (clone 1F3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RICTOR {ECO:0000312|EMBL:EAW55980.1}
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Research Areas
Citations (0)

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Background

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

References

Sarbassov D.D.,et al.Curr. Biol. 14:1296-1302(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ohara O.,et al.DNA Res. 9:47-57(2002).

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$ 450.00
Cat# ALS14493
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