|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:40000-1:80000), IHC-P (2.5 µg/ml), WB (1:200-1:500)|
|Other Names||Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80, gp80, CD126, IL6R|
|Target/Specificity||Not yet tested in other species.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||IL6R / IL6 Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.|
|Cellular Location||Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum|
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Provided below are standard protocols that you may find useful for product applications.
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Yamasaki K.,et al.Science 241:825-828(1988).
Yamasaki K.,et al.Proc. Jpn. Acad., B, Phys. Biol. Sci. 64:209-211(1988).
Schooltink H.,et al.Biochem. J. 277:659-664(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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