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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ABCB5 Antibody   

ABCB5 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - ABCB5 Antibody ALS14504
    Anti-ABCB5 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q2M3G0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 139kDa
Dilution IHC-P (2.5 µg/ml), WB (1:1000-1:4000),
Additional Information
Gene ID 340273
Other Names ATP-binding cassette sub-family B member 5, ABCB5 P-gp, P-glycoprotein ABCB5, ABCB5
Target/Specificity This Polyclonal antibody is directed against human ABCB5 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCB5. Cross-reactivity with ABCB5 from other sources has not been determined.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsABCB5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB5
Function Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}
Tissue Location Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Volume 50 µl
Research Areas
Citations (0)

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Background

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

References

Frank N.Y.,et al.J. Biol. Chem. 278:47156-47165(2003).
Chen K.G.,et al.Pigment Cell Res. 18:102-112(2005).
Wilson B.J.,et al.Cancer Res. 71:5307-5316(2011).
Kawanobe T.,et al.Biochem. Biophys. Res. Commun. 418:736-741(2012).
Meij I.C.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14504
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