|Application ||WB, IHC-P, E|
|Dilution||IHC-P (2.5 µg/ml), WB (1:500-1:1000),|
|Other Names||Calcium-activated chloride channel regulator 1, 3.4.-.-, Calcium-activated chloride channel family member 1, hCLCA1, Calcium-activated chloride channel protein 1, CaCC-1, hCaCC-1, CLCA1, CACC1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||GOB5 / CLCA1 Antibody (clone 1C4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.|
|Cellular Location||Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli|
|Tissue Location||Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.|
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May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Gruber A.D.,et al.Genomics 54:200-214(1998).
Agnel M.,et al.FEBS Lett. 455:295-301(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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