|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Protein prune homolog, hPrune, 18.104.22.168, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||PRUNE Antibody (clone 1C11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.|
|Cellular Location||Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed|
|Tissue Location||Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas|
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Provided below are standard protocols that you may find useful for product applications.
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Reymond A.,et al.Oncogene 18:7244-7252(1999).
Zollo M.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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