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TNFRSF18 / GITR Antibody (clone 2H4)

Mouse Monoclonal Antibody

     
  • WB - TNFRSF18 / GITR Antibody (clone 2H4) ALS14523
    TNFRSF18 monoclonal antibody, clone 2H4.
  • WB - TNFRSF18 / GITR Antibody (clone 2H4) ALS14523
    TNFRSF18 monoclonal antibody, clone 2H4. Western blot of TNFRSF18 expression in NIH/3T3.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y5U5
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 2H4
Calculated MW 26kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 8784
Other Names Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, TNFRSF18, AITR, GITR
Target/Specificity Human TNFRSF18
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTNFRSF18 / GITR Antibody (clone 2H4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF18
Synonyms AITR, GITR
Function Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in lymph node, peripheral blood leukocytes and weakly in spleen
Research Areas
Citations (0)

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Background

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

References

Gurney A.L.,et al.Curr. Biol. 9:215-218(1999).
Kwon B.,et al.J. Biol. Chem. 274:6056-6061(1999).
Nocentini G.,et al.Cell Death Differ. 7:408-410(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14523
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