|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, TNFRSF18, AITR, GITR|
|Reconstitution & Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TNFRSF18 / GITR Antibody (clone 2H4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in lymph node, peripheral blood leukocytes and weakly in spleen|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Gurney A.L.,et al.Curr. Biol. 9:215-218(1999).
Kwon B.,et al.J. Biol. Chem. 274:6056-6061(1999).
Nocentini G.,et al.Cell Death Differ. 7:408-410(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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