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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP2R2B Antibody (clone 1F3)   

PPP2R2B Antibody (clone 1F3)

Mouse Monoclonal Antibody

     
  • IP - PPP2R2B Antibody (clone 1F3) ALS14537
    Immunoprecipitation of PPP2R2B transfected lysate using anti-PPP2R2B monoclonal antibody and...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession Q00005
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F3
Calculated MW 52kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 5521
Other Names Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform, PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta, PPP2R2B
Target/Specificity Human PPP2R2B
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPPP2R2B Antibody (clone 1F3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2R2B
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).
Cellular Location Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane
Tissue Location Brain.
Research Areas
Citations (0)

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Background

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).

References

Mayer R.E.,et al.Biochemistry 30:3589-3597(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Strausberg R.L.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14537
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