|Application ||WB, IHC-P, IF, ICC, IP|
|Reactivity||Human, Mouse, Rat|
|Dilution||ICC (0.1-1 µg/ml), IHC-P (1:50), IP (1-10 µg/ml), WB (1-10 µg/ml) ,|
|Other Names||Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1, HCN1, BCNG1|
|Target/Specificity||Detects ~100 kD protein. No cross reactivity against HCN2.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HCN1 Antibody (aa778-910, clone S70-28) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Schmutz J.,et al.Nature 431:268-274(2004).
Santoro B.,et al.Cell 93:717-729(1998).
Gill C.H.,et al.Br. J. Pharmacol. 143:411-421(2004).
Nava C.,et al.Nat. Genet. 46:640-645(2014).
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