|Application ||WB, IHC-P, E|
|Dilution||IHC-P (2.5-3.75 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Mitogen-activated protein kinase kinase kinase kinase 1, 220.127.116.11, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1|
|Target/Specificity||Human MAP4K1. This antibody is expected to recognise isoform 1 (NP_001036065.1) and isoform 2 (NP_009112.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MAP4K1 / HPK1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.|
|Tissue Location||Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Hu M.C.-T.,et al.Genes Dev. 10:2251-2264(1996).
Grimwood J.,et al.Nature 428:529-535(2004).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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