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TRIM69 / Trif Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86WT6 |
| Reactivity | Human, Rabbit, Monkey, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 57kDa |
| Dilution | ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), |
| Gene ID | 140691 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM69, 6.3.2.-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36 |
| Target/Specificity | Human TRIM69 / RNF36. This antibody is expected to recognize both reported isoforms (NP_892030.3; NP_542783.2). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | TRIM69 / Trif Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM69 |
|---|---|
| Synonyms | RNF36 |
| Function | E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Plays also a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411). |
| Cellular Location | Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.
References
Merla G.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Corcoran M.,et al.Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
Fan M.M.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
Han Y.,et al.Biochem. Biophys. Res. Commun. 429:6-11(2012).
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