MAML1 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q92585 |
Reactivity | Human, Mouse, Monkey, Pig |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 108kDa |
Dilution | ELISA (1:128000), IHC-P (2.5-3.75 µg/ml), WB (0.1-0.3 µg/ml) |
Gene ID | 9794 |
---|---|
Other Names | Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632) |
Target/Specificity | Human MAML1. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | MAML1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAML1 (HGNC:13632) |
---|---|
Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. |
Cellular Location | Nucleus speckle. Note=Nuclear, in a punctate manner |
Tissue Location | Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen |
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Background
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
References
Nagase T.,et al.DNA Res. 3:17-24(1996).
Wu L.,et al.Nat. Genet. 26:484-489(2000).
Kitagawa M.,et al.Mol. Cell. Biol. 21:4337-4346(2001).
Fryer C.J.,et al.Genes Dev. 16:1397-1411(2002).
Fryer C.J.,et al.Mol. Cell 16:509-520(2004).
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