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AGO1 / EIF2C Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - AGO1 / EIF2C Antibody (Internal) ALS14565
    Anti-EIF2C1 / AGO1 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9UL18
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 97kDa
Dilution ELISA (1:16000), IHC-P (2.5-3.75 µg/ml),
Additional Information
Gene ID 26523
Other Names Protein argonaute-1, Argonaute1, hAgo1, Argonaute RISC catalytic component 1, Eukaryotic translation initiation factor 2C 1, eIF-2C 1, eIF2C 1, Putative RNA-binding protein Q99, AGO1, EIF2C1
Target/Specificity Human EIF2C1 / AGO1. This product is not expected to cross-react with EIF2C2, EIF2C3 and EIF2C4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAGO1 / EIF2C Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGO1
Synonyms EIF2C1
Function Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Cellular Location Cytoplasm, P-body
Volume 100 µl
Research Areas
Citations (0)

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Background

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

References

Koesters R.,et al.Genomics 61:210-218(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Meister G.,et al.Mol. Cell 15:185-197(2004).
Meister G.,et al.Curr. Biol. 15:2149-2155(2005).
Janowski B.A.,et al.Nat. Struct. Mol. Biol. 13:787-792(2006).

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$ 395.00
Cat# ALS14565
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