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AGO1 / EIF2C Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9UL18 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 97kDa |
| Dilution | ELISA (1:16000), IHC-P (2.5-3.75 µg/ml), |
| Gene ID | 26523 |
|---|---|
| Other Names | Protein argonaute-1, Argonaute1, hAgo1, Argonaute RISC catalytic component 1, Eukaryotic translation initiation factor 2C 1, eIF-2C 1, eIF2C 1, Putative RNA-binding protein Q99, AGO1, EIF2C1 |
| Target/Specificity | Human EIF2C1 / AGO1. This product is not expected to cross-react with EIF2C2, EIF2C3 and EIF2C4. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | AGO1 / EIF2C Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGO1 |
|---|---|
| Synonyms | EIF2C1 |
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). |
| Cellular Location | Cytoplasm, P-body |
| Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
References
Koesters R.,et al.Genomics 61:210-218(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Meister G.,et al.Mol. Cell 15:185-197(2004).
Meister G.,et al.Curr. Biol. 15:2149-2155(2005).
Janowski B.A.,et al.Nat. Struct. Mol. Biol. 13:787-792(2006).
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