|Application ||WB, IHC-P, Flo|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (1-3 µg/ml),|
|Other Names||Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TLR5, TIL3|
|Target/Specificity||KLH-conjugated synthetic peptide corresponding to a portion of human TLR5 found between amino acids 300-350. It will cross-react with mouse and rat TLR5.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||TLR5 Antibody (aa300-350) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis|
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Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Chaudhary P.M.,et al.Blood 91:4020-4027(1998).
Seya T.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Wlasiuk G.,et al.Mol. Biol. Evol. 26:937-949(2009).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).
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