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ABRI / ITM2B Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - ABRI / ITM2B Antibody (Internal) ALS14582
    ITM2B antibody (1 ug/ml) staining of Human Hippocampus lysate (35 ug protein/ml in RIPA buffer).
  • IHC - ABRI / ITM2B Antibody (Internal) ALS14582
    Anti-ITM2B antibody IHC of human small intestine, myenteric plexus.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y287
Reactivity Human, Monkey, Horse, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 30kDa
Dilution ELISA (1:8000), IHC-P (2.5-3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 9445
Other Names Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2
Target/Specificity Human ITM2B.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsABRI / ITM2B Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITM2B
Synonyms BRI, BRI2
Function Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.
Cellular Location Integral membrane protein 2B: Golgi apparatus membrane; Single-pass type II membrane protein. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted Bri23 peptide: Secreted. Note=Detected in the cerebral spinal fluid (CSF).
Tissue Location Ubiquitous. Expressed in brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.

References

Vidal R.,et al.Nature 399:776-781(1999).
Vidal R.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:4920-4925(2000).
Ren S.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14582
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