|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (0.03-0.1 µg/ml)|
|Other Names||Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2|
|Target/Specificity||Human CNN2. This antibody is expected to recognize both reported isoforms (NP_004359.1; NP_958434.1), but it is not expected to cross-react with CCN3.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CNN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.|
|Tissue Location||Heart and smooth muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Masuda H.,et al.J. Biochem. 120:415-424(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kuromitsu J.,et al.Mol. Cell. Biol. 17:707-712(1997).
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