|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Chicken, Opossum|
|Dilution||IHC-P (1:100), WB (1:500-1:1000),|
|Other Names||Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, FBI-1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21, TIP21, Zinc finger protein 857A, ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A|
|Target/Specificity||A portion of amino acid 1-50 of human Pokemon|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||ZBTB7A / Pokemon Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FBI1, LRF, ZBTB7, ZNF857A|
|Function||Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).|
|Tissue Location||Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
Morrison D.J.,et al.Nucleic Acids Res. 27:1251-1262(1999).
Jansa P.,et al.Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Davies J.M.,et al.Oncogene 18:365-375(1999).
Maeda T.,et al.Nature 433:278-285(2005).
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