|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:20000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1|
|Target/Specificity||hnRNP A1 Antibody detects endogenous levels of total hnRNP A1 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HNRPA1 / HnRNP A1 Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
Biamonti G.,et al.J. Mol. Biol. 207:491-503(1989).
Buvoli M.,et al.Nucleic Acids Res. 16:3751-3770(1988).
Knudsen S.M.,et al.Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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