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AICDA / AID Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - AICDA / AID Antibody (N-Terminus) ALS14656
    Anti-AICDA antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9GZX7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (1:100-1:200), WB (1:500-1:2000),
Additional Information
Gene ID 57379
Other Names Single-stranded DNA cytosine deaminase, 3.5.4.38, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA, AID
Target/Specificity Human 24 kD AICDA protein
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAICDA / AID Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AICDA
Synonyms AID
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm
Tissue Location Strongly expressed in lymph nodes and tonsils.
Volume 100 µl
Research Areas
Citations (0)

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Background

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

References

Muto T.,et al.Genomics 68:85-88(2000).
Revy P.,et al.Cell 102:565-575(2000).
Martin A.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002).
Roa S.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14656
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