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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   HIP1 Antibody (clone 1F12)   

HIP1 Antibody (clone 1F12)

Mouse Monoclonal Antibody

     
  • WB - HIP1 Antibody (clone 1F12) ALS14667
    HIP1 monoclonal antibody, clone 1F12 Western blot of HIP1 expression in HeLa.
  • WB - HIP1 Antibody (clone 1F12) ALS14667
    Western blot of HIP1 expression in transfected 293T cell line by HIP1 monoclonal antibody, clone...
  • IP - HIP1 Antibody (clone 1F12) ALS14667
    Immunoprecipitation of HIP1 transfected lysate using anti-HIP1 monoclonal antibody and Protein A...
  • IHC - HIP1 Antibody (clone 1F12) ALS14667
    Anti-HIP1 antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession O00291
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F12
Calculated MW 116kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3092
Other Names Huntingtin-interacting protein 1, HIP-1, Huntingtin-interacting protein I, HIP-I, HIP1
Target/Specificity Human HIP1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHIP1 Antibody (clone 1F12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIP1
Function Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Cellular Location Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR
Tissue Location Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer
Research Areas
Citations (0)

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Background

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

References

Kim R.N.,et al.Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Gervais F.G.,et al.Nat. Cell Biol. 4:95-105(2002).
Huq A.H.M.M.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14667
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