|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Cocaine esterase, 18.104.22.168, Carboxylesterase 2, CE-2, hCE-2, 22.214.171.124, Methylumbelliferyl-acetate deacetylase 2, 126.96.36.199, CES2, ICE|
|Target/Specificity||synthetic peptide corresponding to C-terminal residues of human CES2(Carboxylesterase 2 precursor)|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CES2 / Esterase Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Schwer H.,et al.Biochem. Biophys. Res. Commun. 233:117-120(1997).
Pindel E.V.,et al.J. Biol. Chem. 272:14769-14775(1997).
Sone T.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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