|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Cocaine esterase, 126.96.36.199, Carboxylesterase 2, CE-2, hCE-2, 188.8.131.52, Methylumbelliferyl-acetate deacetylase 2, 184.108.40.206, CES2, ICE|
|Target/Specificity||synthetic peptide corresponding to C-terminal residues of human CES2(Carboxylesterase 2 precursor)|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CES2 / Esterase Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.|
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Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Schwer H.,et al.Biochem. Biophys. Res. Commun. 233:117-120(1997).
Pindel E.V.,et al.J. Biol. Chem. 272:14769-14775(1997).
Sone T.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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