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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PEA15 / PEA-15 Antibody (aa81-130)   

PEA15 / PEA-15 Antibody (aa81-130)

Rabbit Polyclonal Antibody

     
  • IF - PEA15 / PEA-15 Antibody (aa81-130) ALS14724
    Immunofluorescence of HeLa cells, using PEA-15 antibody.
  • WB - PEA15 / PEA-15 Antibody (aa81-130) ALS14724
    Western blot of extracts from Jurkat cells, treated with PMA 125 ng/ml 30', using PEA-15 antibody.
  • IHC - PEA15 / PEA-15 Antibody (aa81-130) ALS14724
    Anti-PEA15 antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q15121
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 15kDa
Dilution ELISA (1:40000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 8682
Other Names Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED, PEA15
Target/Specificity PEA-15 antibody detects endogenous levels of total PEA-15 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPEA15 / PEA-15 Antibody (aa81-130) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEA15
Function Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Cellular Location Cytoplasm. Note=Associated with microtubules
Tissue Location Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls
Volume 50 µl
Research Areas
Citations (0)

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Background

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

References

Estelles A.,et al.J. Biol. Chem. 271:14800-14806(1996).
Condorelli G.,et al.EMBO J. 17:3858-3866(1998).
Wolford J.K.,et al.Gene 241:143-148(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14724
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