|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4|
|Target/Specificity||TIMP4 Antibody detects endogenous levels of total TIMP4 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TIMP4 Antibody (aa175-224) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.|
|Tissue Location||Abundant in heart and present at low levels in many other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.
Greene J.,et al.J. Biol. Chem. 271:30375-30380(1996).
Olson T.M.,et al.Genomics 51:148-151(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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