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LAMB1 / Laminin Beta 1 Antibody (aa1721-1770)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P07942 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 198kDa |
| Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 3912 |
|---|---|
| Other Names | Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10 subunit beta, Laminin-12 subunit beta, Laminin-2 subunit beta, Laminin-6 subunit beta, Laminin-8 subunit beta, LAMB1 |
| Target/Specificity | LAMB1 Antibody detects endogenous levels of total LAMB1 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | LAMB1 / Laminin Beta 1 Antibody (aa1721-1770) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LAMB1 |
|---|---|
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. |
| Cellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
References
Vuolteenaho R.,et al.J. Biol. Chem. 265:15611-15616(1990).
Pikkarainen T.,et al.J. Biol. Chem. 262:10454-10462(1987).
Scherer S.W.,et al.Science 300:767-772(2003).
Jaye M.,et al.Am. J. Hum. Genet. 41:605-615(1987).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
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