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DES / Desmin Antibody (clone D9)

Mouse Monoclonal Antibody

     
  • IHC - DES / Desmin Antibody (clone D9) ALS14875
    Anti-DES / Desmin antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-Fr
Primary Accession P17661
Reactivity Human, Mouse, Rat, Rabbit, Pig, Chicken
Host Mouse
Clonality Monoclonal
Clone Names D9
Calculated MW 54kDa
Dilution IHC-Fr (1:25-1:200), IHC-P (10 µg/ml), WB (1:100-1:1000)
Additional Information
Gene ID 1674
Other Names Desmin, DES
Target/Specificity Reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma. Cross-reacts with most mammals.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDES / Desmin Antibody (clone D9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction.
Cellular Location Cytoplasm, myofibril, sarcomere, Z line Cytoplasm. Cell membrane, sarcolemma. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes (PubMed:24200904, PubMed:26724190).
Research Areas
Citations (0)

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Background

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

References

Li Z.,et al.Gene 78:243-254(1989).
Li Z.,et al.J. Biol. Chem. 266:6562-6570(1991).
Vicart P.,et al.Hum. Genet. 98:422-429(1996).
Goldfarb L.G.,et al.Nat. Genet. 19:402-403(1998).
Li D.,et al.Circulation 100:461-464(1999).

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$ 395.00
Cat# ALS14875
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