|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (0.25-1 µg/ml),|
|Other Names||Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||IKZF3 / AIOLOS Antibody (aa350-400) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.
Hosokawa Y.,et al.Genomics 61:326-329(1999).
Liippo J.P.,et al.Eur. J. Immunol. 31:3469-3474(2001).
Caballero R.,et al.J. Cell Sci. 120:2619-2630(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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