|Reactivity||Human, Mouse, Rat, Monkey, Horse, Bovine, Dog|
|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||Furin, 18.104.22.168, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, PACE, PCSK3|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||FURIN Antibody (aa740-790) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FUR, PACE, PCSK3|
|Function||Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin|
|Tissue Location||Seems to be expressed ubiquitously.|
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Provided below are standard protocols that you may find useful for product applications.
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
van den Ouweland A.M.W.,et al.Nucleic Acids Res. 18:664-664(1990).
Wise R.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:9378-9382(1990).
Barr P.J.,et al.DNA Cell Biol. 10:319-328(1991).
Van den Ouweland A.M.W.,et al.Nucleic Acids Res. 17:7101-7102(1989).
Roebroek A.J.M.,et al.EMBO J. 5:2197-2202(1986).
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