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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD79B Antibody (Intracellular, clone AT107-2)   

CD79B Antibody (Intracellular, clone AT107-2)

Rat Monoclonal Antibody

     
  • IHC - CD79B Antibody (Intracellular, clone AT107-2) ALS14919
    Anti-CD79B antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP, Flo
Primary Accession P40259
Reactivity Human, Rat, Pig, Dog
Host Rat
Clonality Monoclonal
Clone Names AT107-2
Calculated MW 26kDa
Dilution Flo (1:50-1:100), IHC-P (2 µg/ml),
Additional Information
Gene ID 974
Other Names B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b, CD79B, B29, IGB
Target/Specificity Recognizes an intracellular region of human and mouse CD79b, a cell surface antigen expressed by B lymphocytes. The CD79b molecule (also known as Ig beta and B29) associates with CD79a to form a heterodimer that is covalently linked to surface immuno ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCD79B Antibody (Intracellular, clone AT107-2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD79B
Synonyms B29, IGB
Function Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue Location B-cells.
Research Areas
Citations (0)

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Background

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

References

Mueller B.S.,et al.Eur. J. Immunol. 22:1621-1625(1992).
Wood W.J. Jr.,et al.Genomics 16:187-192(1993).
Hashimoto S.,et al.J. Immunol. 150:491-498(1993).
Hashimoto S.,et al.Immunogenetics 40:145-149(1994).
Hashimoto S.,et al.Mol. Immunol. 32:651-659(1995).

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$ 395.00
Cat# ALS14919
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