|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Cyclin-O, CCNO|
|Target/Specificity||Recognizes CyclinO, a 38 kDa member of the cyclin family expressed mainly during the G1 phase.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CCNO / UNG2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.|
|Cellular Location||Cytoplasm. Note=Localizes to the apical part of cytoplasm|
|Tissue Location||Present in respiratory cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
Muller S.J.,et al.Biochim. Biophys. Acta 1088:197-207(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Muller S.J.,et al.J. Biol. Chem. 268:1310-1319(1993).
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