|Application ||WB, IHC-P, IHC-Fr, Flo|
|Dilution||Flo (1:50-1:200), IHC-Fr (1-10 µg/ml), IHC-P (10 µg/ml)|
|Other Names||Complement receptor type 1, C3b/C4b receptor, CD35, CR1, C3BR|
|Target/Specificity||Recognizes CD35, a single chain cell surface glycoprotein which exists in four allotypic forms (A, B, C, D) of 190kD, 220kD, 160kD and 250kD respectively. The molecule is expressed by granulocytes, monocytes, B cells and some T cells. Functionally CD ...|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CR1 / CD35 Antibody (clone E11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates cellular binding of particles and immune complexes that have activated complement.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
Mediates cellular binding of particles and immune complexes that have activated complement.
Klickstein L.B.,et al.J. Exp. Med. 168:1699-1717(1988).
Vik D.P.,et al.J. Immunol. 151:6214-6224(1993).
Gregory S.G.,et al.Nature 441:315-321(2006).
Wong W.W.,et al.J. Exp. Med. 169:847-863(1989).
Hourcade D.,et al.J. Exp. Med. 168:1255-1270(1988).
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