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EPB41L4B Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9H329 |
| Reactivity | Human, Rabbit, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 100kDa |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), |
| Gene ID | 54566 |
|---|---|
| Other Names | Band 4.1-like protein 4B, FERM-containing protein CG1, Protein EHM2, EPB41L4B, EHM2 |
| Target/Specificity | Human EPB41L4B. This antibody is expected to recognise both reported isoforms (NP_060894.2; NP_061987.3). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | EPB41L4B Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPB41L4B (HGNC:19818) |
|---|---|
| Function | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid- induced cell differentiation (PubMed:14521927). |
| Cellular Location | Cytoplasm. Cell junction, tight junction Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. |
| Tissue Location | Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Chadwick B.P.,et al.Mamm. Genome 11:81-83(2000).
Shimizu K.,et al.Genomics 65:113-120(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
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