|Application ||IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml),|
|Other Names||Melatonin receptor type 1B, Mel-1B-R, Mel1b receptor, MTNR1B|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MTNR1B / MT2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in retina and less in brain and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Reppert S.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1995).
Ebisawa T.,et al.Neurosci. Lett. 280:29-32(2000).
King M.M.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
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