|Application ||WB, IHC-P, IF, ICC, IP|
|Reactivity||Human, Mouse, Rat|
|Dilution||ICC (0.1-1 µg/ml), IHC-P (10 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) ,|
|Other Names||Short transient receptor potential channel 7, TrpC7, Transient receptor protein 7, TRP-7, hTRP7, TRPC7, TRP7|
|Target/Specificity||Detects ~100 kD protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TRPC7 Antibody (aa845-862, clone S64A-36) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Nucleus envelope|
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Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Murphy C.T.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Xu S.-Z.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Aptel H.,et al.Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Lussier M.P.,et al.J. Biol. Chem. 280:19393-19400(2005).
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