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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FLNA / Filamin A Antibody (aa2121-2170)   

FLNA / Filamin A Antibody (aa2121-2170)

Rabbit Polyclonal Antibody

     
  • WB - FLNA / Filamin A Antibody (aa2121-2170) ALS15008
    Western blot of extracts from 293 cells, treated with EGF 200 ng/ml 5', using Filamin Antibody.
  • IHC - FLNA / Filamin A Antibody (aa2121-2170) ALS15008
    Anti-FLNA / FMD antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P21333
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 281kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 2316
Other Names Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1
Target/Specificity Filamin A Antibody detects endogenous levels of total Filamin A protein.
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsFLNA / Filamin A Antibody (aa2121-2170) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FLNA
Synonyms FLN, FLN1
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintainance (By similarity).
Cellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

References

Gorlin J.B.,et al.J. Cell Biol. 111:1089-1105(1990).
Patrosso M.C.,et al.Genomics 21:71-76(1994).
Chen E.Y.,et al.Hum. Mol. Genet. 5:659-668(1996).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS15008
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