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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   MAP3K5 / ASK1 Antibody (aa49-98)   

MAP3K5 / ASK1 Antibody (aa49-98)

Rabbit Polyclonal Antibody

     
  • IHC - MAP3K5 / ASK1 Antibody (aa49-98) ALS15014
    Anti-MAP3K5 / ASK1 antibody IHC of human skin, sweat ducts.
  • IHC - MAP3K5 / ASK1 Antibody (aa49-98) ALS15014
    Anti-MAP3K5 / ASK1 antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q99683
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 155kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 4217
Other Names Mitogen-activated protein kinase kinase kinase 5, 2.7.11.25, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, MAP3K5, ASK1, MAPKKK5, MEKK5
Target/Specificity ASK1 (Ab-83) Antibody detects endogenous levels of total ASK1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsMAP3K5 / ASK1 Antibody (aa49-98) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K5
Synonyms ASK1, MAPKKK5, MEKK5
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Cellular Location Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region
Tissue Location Abundantly expressed in heart and pancreas.
Volume 50 µl
Research Areas
Citations (0)

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Background

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

References

Wang X.S.,et al.J. Biol. Chem. 271:31607-31611(1996).
Ichijo H.,et al.Science 275:90-94(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Saitoh M.,et al.EMBO J. 17:2596-2606(1998).

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$ 395.00
Cat# ALS15014
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