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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   APC Antibody (aa2794-2843)   

APC Antibody (aa2794-2843)

Rabbit Polyclonal Antibody

     
  • WB - APC Antibody (aa2794-2843) ALS15035
    Western blot of extracts from COLO205 cells, using APC Antibody.
  • IHC - APC Antibody (aa2794-2843) ALS15035
    Anti-APC antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P25054
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 312kDa
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 324
Other Names Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5, APC, DP2.5
Target/Specificity APC Antibody detects endogenous levels of total APC protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsAPC Antibody (aa2794-2843) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APC
Synonyms DP2.5
Function Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Cellular Location Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).
Tissue Location Expressed in a variety of tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

References

Joslyn G.,et al.Cell 66:601-613(1991).
Kinzler K.W.,et al.Science 253:661-665(1991).
Kawasaki Y.,et al.Science 289:1194-1197(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Miki Y.,et al.Cancer Res. 52:643-645(1992).

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$ 395.00
Cat# ALS15035
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