|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Granzyme B, 220.127.116.11, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB|
|Target/Specificity||Granzyme B Antibody detects endogenous levels of total Granzyme B protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||GZMB / Granzyme B Antibody (aa10-59) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CGL1, CSPB, CTLA1, GRB|
|Function||This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.|
|Cellular Location||Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Schmid J.,et al.J. Immunol. 139:250-256(1987).
Caputo A.,et al.J. Biol. Chem. 263:6363-6369(1988).
Trapani J.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928(1988).
Klein J.L.,et al.Genomics 5:110-117(1989).
Caputo A.,et al.J. Immunol. 145:737-744(1990).
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