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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAN Antibody (aa167-216)   

RAN Antibody (aa167-216)

Rabbit Polyclonal Antibody

     
  • WB - RAN Antibody (aa167-216) ALS15057
    Western blot of extracts from LOVO cells, using RAN Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P62826
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 5901
Other Names GTP-binding nuclear protein Ran, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, RAN, ARA24
Target/Specificity RAN Antibody detects endogenous levels of total RAN protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsRAN Antibody (aa167-216) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAN
Synonyms ARA24
Function GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
Cellular Location Nucleus. Nucleus envelope. Cytoplasm. Melanosome {ECO:0000250|UniProtKB:P62827}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P62827}
Tissue Location Expressed in a variety of tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.

References

Drivas G.T.,et al.Mol. Cell. Biol. 10:1793-1798(1990).
Matsumoto T.,et al.Cell 66:347-360(1991).
Ren M.,et al.J. Cell Biol. 120:313-323(1993).
Hsiao P.-W.,et al.J. Biol. Chem. 274:20229-20234(1999).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).

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$ 395.00
Cat# ALS15057
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