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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SENP1 Antibody (aa1-50)   

SENP1 Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • WB - SENP1 Antibody (aa1-50) ALS15082
    Western blot of extracts from Jurkat cells, using SENP1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9P0U3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 29843
Other Names Sentrin-specific protease 1, 3.4.22.68, Sentrin/SUMO-specific protease SENP1, SENP1
Target/Specificity SENP1 Antibody detects endogenous levels of total SENP1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSENP1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SENP1
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
Tissue Location Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Volume 50 µl
Research Areas
Citations (0)

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Background

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.

References

Gong L.,et al.J. Biol. Chem. 275:3355-3359(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Bailey D.,et al.J. Biol. Chem. 279:692-703(2004).
Cheng J.,et al.Mol. Cell. Biol. 24:6021-6028(2004).

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$ 395.00
Cat# ALS15082
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