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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9P0U3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73kDa |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 29843 |
|---|---|
| Other Names | Sentrin-specific protease 1, 3.4.22.68, Sentrin/SUMO-specific protease SENP1, SENP1 |
| Target/Specificity | SENP1 Antibody detects endogenous levels of total SENP1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | SENP1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SENP1 |
|---|---|
| Function | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). |
| Cellular Location | Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus |
| Tissue Location | Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.
References
Gong L.,et al.J. Biol. Chem. 275:3355-3359(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Bailey D.,et al.J. Biol. Chem. 279:692-703(2004).
Cheng J.,et al.Mol. Cell. Biol. 24:6021-6028(2004).
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