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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LMNA / Lamin A/C Antibody (aa181-230)   

LMNA / Lamin A/C Antibody (aa181-230)

Rabbit Polyclonal Antibody

     
  • WB - LMNA / Lamin A/C Antibody (aa181-230) ALS15146
    Western blot of extracts from HeLa cells, treated with Etoposide 25 uM 60', using Lamin A...
  • IHC - LMNA / Lamin A/C Antibody (aa181-230) ALS15146
    Anti-LMNA / Lamin A/C antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02545
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 74kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 4000
Other Names Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Target/Specificity Lamin A (Cleaved-Asp230) Antibody detects endogenous levels of fragment of activated Lamin A resulting from cleavage adjacent to Asp230.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsLMNA / Lamin A/C Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMNA
Synonyms LMN1
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
Cellular Location Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C
Tissue Location In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Volume 100 µl
Research Areas
Citations (0)

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Background

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

References

McKeon F.D.,et al.Nature 319:463-468(1986).
Fisher D.Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454(1986).
Sylvius N.,et al.J. Med. Genet. 42:639-647(2005).
Csoka A.B.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS15146
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(40 western blots)
Availability: 5 days
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